Screening of Cannabinoids
Most of the traditional methodologies for the determination of cannabinoids are based on solvent extraction, fi ltration, and concentration. These techniques are cumbersome, time-consuming, and suffer from analyst-to-analyst variability while producing data of limited value. Many laboratories routinely “screen” each sample to quickly determine the potential for matrix interference and instrument contamination while providing an estimate of the target compound’s concentration. A good “screening” method is simple (that is, minimal or no sample preparation), fast (analysis in less than 5 min), and semiquantitative. This article describes how thermal desorption (TD)-gas
chromatography–mass spectrometry (GC–MS) analysis eliminates conventional sample preparation regimes and can be used as a good rapid screening technique.